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Principles of ethylene oxide sterilization

Principles of ethylene oxide sterilization

  • Time of issue:2021-12-17
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Principles of ethylene oxide sterilization

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  • Time of issue:2021-12-17
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1. Alkylation
 
When ethylene oxide acts, its cyclic structure is broken, and it is alkylated with amino-NH2, carboxy-C00H, hydroxyl-OH and other active groups on the protein in the bacterial body through hydroxylation (-CH2-CH2-OH). It acts as an obstacle to the enzyme metabolism process, thereby destroying the metabolism of the bacteria and causing the death of microorganisms. So as to achieve the purpose of killing microorganisms.
 
2. YZ biological enzyme activity
 
Ethylene oxide can make YZ microorganism's various enzyme activities, such as phosphate dehydrogenase, cholinesterase and other oxidases, hinder the completion of the normal metabolic process of microorganisms and lead to its death.
 
3. The killing effect on microorganisms
 
Ethylene oxide liquid and gas have a strong antibacterial effect. In contrast, gas has a stronger antibacterial effect and is generally used for disinfection and sterilization of its gas.
 
Ethylene oxide is a GX type bactericide, which has a powerful killing and inactivating effect on bacterial spores, fungi, viruses, etc. When ethylene oxide comes into contact with microorganisms, but the microorganisms contain enough water, the interaction between ethylene oxide and microorganisms is a typical reaction. For the dose of inactivating purely cultured microorganisms, the response curve is a straight line on the semi-logarithmic value.
 
This rule applies to all microorganisms. Different types of microorganisms have different resistance to ethylene oxide, but the difference is not significant. The resistance of bacterial spores to ethylene oxide is only two times stronger than that of propagules, and no microorganisms with high resistance to ethylene oxide are found to be genetically determined. Bacterial spores are highly resistant to ethylene oxide, among which the spores of Bacillus subtilis var. black are strong.

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Ethylene

Ethylene Oxide Chemical Safety Data Sheet

It is a central nervous system depressant, stimulant and protoplasmic poison.
2016-10-11

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